The Coptic Orthodox Church (Coptic: Ϯⲉⲕ̀ⲕⲗⲏⲥⲓⲁ ⲛ̀ⲣⲉⲙⲛ̀ⲭⲏⲙⲓ ⲛ̀ⲟⲣⲑⲟⲇⲟⲝⲟⲥ, romanized: Ti.eklyseya en.remenkimi en.orthodoxos, lit. 'the Egyptian Orthodox Church'; Arabic: الكنيسة القبطية الأرثوذكسية, romanized: al-Kanīsa al-Qibṭiyya al-ʾUrṯūḏuksiyya), also known as the Coptic Orthodox Patriarchate of Alexandria, is an Oriental Orthodox Christian church based in Egypt, serving Africa and the Middle East. The head of the church and the See of Alexandria is the Pope of Alexandria on the Holy Apostolic See of Saint Mark, who also carries the title of Father of fathers, Shepherd of shepherds, Ecumenical Judge and the 13th among the Apostles. The See of Alexandria is titular. The Coptic Pope presides from Saint Mark's Coptic Orthodox Cathedral in the Abbassia District in Cairo. The church follows the Coptic Rite for its liturgy, prayer and devotional patrimony. Christians in Egypt total about four million people, and Coptic Christians make up Egypt’s largest and most significant minority population, and the largest population of Christians in the Middle East.

Coptic Orthodox tradition claims that the Coptic Church was established by Mark, an apostle and evangelist, during the middle of the 1st century (c. AD 42). Due to disputes concerning the nature of Christ, the Oriental Orthodox Churches and the Eastern Orthodox Church schismed after the Council of Chalcedon in AD 451, resulting in a rivalry with the Greek Orthodox Church of Alexandria.

After AD 639, Egypt was ruled by its Islamic conquerors from Arabia. In the 12th century, the church relocated its seat from Alexandria to Cairo. The same century also saw the Copts become a religious minority. During the 14th and 15th centuries, Nubian Christianity was supplanted by Islam. In the 19th and 20th centuries, the larger body of ethnic Egyptian Christians began to call themselves Coptic Orthodox, to distinguish themselves from the Catholic Copts and from the Eastern Orthodox, who are mostly Greek. In 1959, the Ethiopian Orthodox Tewahedo Church was granted autocephaly. This was extended to the Eritrean Orthodox Tewahedo Church in 1998 following the successful Eritrean War of Independence from Ethiopia. Since the 2011 Egyptian revolution, Coptic Christians have suffered increased religious discrimination and violence.